五 经典文献导读

五 经典文献导读

1 第一个癌基因src的发现和癌基因概念的提出

Stehelin D, Varmus HE, Bishop JM, Vogt PK. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976 Mar 11; 260(5547): 170-173.

2 肿瘤抑制基因概念的提出

Klein G. The approaching era of the tumor suppressor genes. Science. 1987 Dec 11; 238(4833): 1539-1545.

3 第一个肿瘤抑制基因p53的发现

Lane DP, Crawford LV. T antigen is bound to a host protein in SV40-transformed cells. Nature. 1979 Mar 15; 278(5701):261-263.

4 信号转导概念的提出

Rodbell M. The role of hormone receptors and GTP-regulatory proteins in membrane transduction. Nature. 1980; 284 (5751): 17–22.

5 TNF的发现

Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci U S A. 1975 Sep; 72(9): 3666-3670.

6 NF-kB的发现

Singh H, Sen R, Baltimore D, Sharp PA. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature, 1986, 319: 154-158

7 酵母中TOR蛋白的发现

Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science. 1991 Aug 23; 253(5022):905-9.

8 哺乳动物mTOR的克隆

Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature. 1994 Jun 30; 369(6483):756-8.

9 第一个人类癌基因ras的发现

Parada LF, Tabin CJ, Shih C, Weinberg RA. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 1982 Jun 10; 297(5866):474-8.

10 激酶Raf-1的发现

Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH Jr, Stephenson JR. Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus. Proc Natl Acad Sci U S A. 1983 Jul; 80(14):4218-22

11 第一个Wnt基因的克隆

Nusse R, Varmus HE. Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome. Cell. 1982 Nov; 31(1):99-109.